Division 2 Sydsvenska Serien 1927–28 was part of the 1927–28 Swedish football season.
| Team | Pld | W | D | L | GF | GA | GD | Pts | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | IFK Malmö | 20 | 16 | 4 | 0 | 66 | – | 16 | +50 | 36 |
| 2 | Kalmar FF | 20 | 12 | 2 | 6 | 57 | – | 37 | +20 | 26 |
| 3 | Malmö FF | 20 | 11 | 4 | 5 | 63 | – | 44 | +19 | 26 |
| 4 | Halmstads BK | 20 | 9 | 4 | 7 | 47 | – | 37 | +10 | 22 |
| 5 | IS Halmia | 20 | 8 | 2 | 10 | 36 | – | 47 | -11 | 18 |
| 6 | Varbergs BoIS | 20 | 7 | 3 | 10 | 36 | – | 51 | -15 | 17 |
| 7 | Varbergs GIF | 20 | 7 | 3 | 10 | 33 | – | 58 | -25 | 17 |
| 8 | Malmö BI | 20 | 7 | 2 | 11 | 40 | – | 48 | -8 | 16 |
| 9 | IFK Hälsingborg | 20 | 7 | 1 | 12 | 48 | – | 56 | -8 | 15 |
| 10 | IFK Kristianstad | 20 | 6 | 3 | 11 | 44 | – | 58 | -14 | 15 |
| 11 | Landskrona IF | 20 | 4 | 4 | 12 | 37 | – | 55 | -18 | 12 |
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